Study setup of the ADU-1805 non-GLP pilot toxicity study in 5–7 years old cynomolgus monkeys. A single dose of ADU-1805 or vehicle was administered i.v. for a duration of 15 min. Vehicle refers to the antibody formulation buffer: 10 mM L-Histidine pH 5.5 containing 0.1 M sodium chloride
| Group | Treatment | Dose | Animals |
|---|---|---|---|
| 1 | Vehicle | – | 1 male / 1 female |
| C2 | ADU-1805 | 0.3 mg/kg | 1 male / 1 female |
| 3 | ADU-1805 | 3 mg/kg | 1 male / 1 female |
| 4 | ADU-1805 | 30 mg/kg | 1 male / 1 female |