Characteristic | Anti-CTLA4 (n=17) | Anti-PD1 (n=16) | P value |
Age (years) | |||
Median | 66 | 63 | 0.866 |
Range | 38–80 | 37–91 | |
Race | |||
White | 15 | 14 | 0.998 |
Black | 1 | 1 | |
Asian | 1 | 1 | |
Sex | |||
Male | 10 | 12 | 0.325 |
Female | 7 | 4 | |
Tumor histology | |||
Adenocarcinoma | 14 | 12 | 0.606 |
Squamous cell carcinoma | 3 | 4 | |
Smoking history | |||
Yes | 12 | 13 | 0.475 |
No | 5 | 3 | |
KPS score at diagnosis | |||
≥80 | 9 | 14 | |
<80 | 8 | 2 | 0.057 |
Prior systemic therapy | |||
Yes | 14 | 9 | 0.103 |
No | 3 | 7 | |
Number of systemic therapy regimens, mean (range) | 2.12 (0–8) | 1.13 (0–4) | 0.157 |
Prior radiation therapy | |||
Yes | 3 | 5 | 0.362 |
No | 14 | 11 | |
Prior immunotherapy | |||
Yes | 2 | 2 | 0.9 |
No | 15 | 14 | |
History of autoimmune disease | |||
Yes | 1 | 1 | 0.736 |
No | 16 | 15 | |
Metastatic sites mean (range) | 3.1 (2–9) | 2.4 (2–6) | 0.207 |
ALC change mean (range) | −28% (1% to −70%) | −19% (−3% to −63%) | 0.148 |
ALC, absolute lymphocyte counts; KPS, Karnofsky performance status.