Table 2

Univariate and multivariate Cox regression analysis of overall survival in each data set

VariablesUnivariate analysisMultivariate analysis
HR95% CI of HRP valueHR95% CI of HRP value
GSE30219
 TILSig (high/low)1.9811.491 to 2.633<0.0011.5841.184 to 2.1180.002
 Age1.0381.024 to 1.053<0.0011.0371.022 to 1.052<0.001
 Gender (male/female)1.7011.082 to 2.6740.0221.3980.886 to 2.2060.150
 Stage (III/IV vs I/II)3.0362.234 to 4.127<0.0012.8102.059 to 3.835<0.001
GSE31210
 TILSig (high/low)2.4221.219 to 4.8120.0122.3221.147 to 4.7030.019
 Age1.0250.978 to 1.0750.3061.0350.988 to 1.0850.147
 Gender (male/female)1.5190.780 to 2.9550.2191.1000.549 to 2.2010.789
 Stage (II /I)4.2322.175 to 8.236<0.0014.2902.164 to 8.502<0.001
TCGA
 TILSig (high/low)1.3051.028 to 1.6560.0281.3381.054 to 1.6980.017
 Age1.0171.003 to 1.0300.0141.0201.006 to 1.0340.004
 Gender (male/female)0.9950.780 to 1.2700.9700.9660.756 to 1.2340.782
 Stage (III/IV vs I/II)1.9011.476 to 2.45<0.0012.0081.555 to 2.592<0.001
  • TCGA, The Cancer Genome Atlas; TILSig, tumor-infiltrating immune-related lncRNA signature.