Table 2

Univariate and multivariate Cox regression analysis of overall survival in each data set

Variables	Univariate analysis			Multivariate analysis
Variables	HR	95% CI of HR	P value	HR	95% CI of HR	P value
GSE30219
TILSig (high/low)	1.981	1.491 to 2.633	<0.001	1.584	1.184 to 2.118	0.002
Age	1.038	1.024 to 1.053	<0.001	1.037	1.022 to 1.052	<0.001
Gender (male/female)	1.701	1.082 to 2.674	0.022	1.398	0.886 to 2.206	0.150
Stage (III/IV vs I/II)	3.036	2.234 to 4.127	<0.001	2.810	2.059 to 3.835	<0.001
GSE31210
TILSig (high/low)	2.422	1.219 to 4.812	0.012	2.322	1.147 to 4.703	0.019
Age	1.025	0.978 to 1.075	0.306	1.035	0.988 to 1.085	0.147
Gender (male/female)	1.519	0.780 to 2.955	0.219	1.100	0.549 to 2.201	0.789
Stage (II /I)	4.232	2.175 to 8.236	<0.001	4.290	2.164 to 8.502	<0.001
TCGA
TILSig (high/low)	1.305	1.028 to 1.656	0.028	1.338	1.054 to 1.698	0.017
Age	1.017	1.003 to 1.030	0.014	1.020	1.006 to 1.034	0.004
Gender (male/female)	0.995	0.780 to 1.270	0.970	0.966	0.756 to 1.234	0.782
Stage (III/IV vs I/II)	1.901	1.476 to 2.45	<0.001	2.008	1.555 to 2.592	<0.001

TCGA, The Cancer Genome Atlas; TILSig, tumor-infiltrating immune-related lncRNA signature.