Table 2

Treatment-related toxicities

Grade 1–2Grade >3All grades
Gastrointestinal
 Elevated akaline phosphatase57%10%67%
 Elevated AST50%3%53%
 Nausea53%0%53%
 Diarrhea47%3%50%
 Elevated ALT37%3%40%
 Abdominal pain33%0%33%
 Constipation33%0%33%
 Vomiting30%0%30%
 Hepatic failure0%3%3%
Dermatological and other
 Fatigue57%0%57%
 Hand-foot syndrome30%13%43%
 Headache40%0%40%
 Pain in extremity37%0%37%
 Back pain33%0%33%
 Sinus tachycardia30%0%30%
 Hypertension20%7%27%
 Edema27%0%27%
 Maculopapular rash13%3%17%
 Peripheral neuropathy17%0%17%
Hematological
 Anemia50%10%60%
 Lymphopenia33%20%53%
 Leukopenia40%0%40%
 Neutropenia17%7%23%
 Thrombocytopenia23%0%23%
Other laboratory abnormalities
 Hyperglycemia83%3%87%
 Hypoalbuminemia33%3%37%
 Hypokalemia30%3%33%
 Acute kidney injury0%3%3%
  • ALT, alanine transaminase; AST, aspartate transaminase.