Comparison of CAR-T and TIL infusion products
| CAR-T n=24 | TIL (n=40–88) | P value | |
| T cell subpopulations | |||
| CD8+ | 58±16 | 63±24 (n=88) | 0.386 |
| CD4+ | 42±17 | 35±24 (n=88) | 0.200 |
| Differentiation status | |||
| TN | 49±18 | 0.05±0.10 (n=88) | ≤0.001 |
| TCM | 17±14 | 2.3±2.5 (n=88) | ≤0.001 |
| TEM | 18±13 | 96.8±3.0 (n=88) | ≤0.001 |
| TEMRA | 15±13 | 0.82±1.5 (n=88) | ≤0.001 |
| Co-stimulatory / co-inhibitory molecules | |||
| CD28 + CD3+ | 47±26 | 52±20 (n=88) | 0.396 |
| PD1 + CD3+ | 26±8 | 26±15 (n=40) | 0.494 |
| LAG3 + CD3+ | 25±11 | 10±4 (n=40) | ≤0.001 |
| TIM3 + CD3+ | 50±15 | 61±14 (n=40) | 0.004 |
| Chemokine receptors | |||
| CCR5 + CD3+ | 12±13 | 80±24 (n=56) | ≤0.001 |
| CCR4 + CD3+ | 33±14 | 27±12 (n=88) | 0.032 |
| CXCR3 + CD3+ | 79±12 | 86±20 (n=88) | 0.076 |
Phenotype analysis of 24 CAR-T cells and 40 to 88 TIL infusion products. Cells were gated on viable cells. TIL, tumor infiltrating lymphocytes, TN (naïve T cells), CD3+CD45RA+CCR7+; TCM (central memory T cells), CD3+CD45RA−CCR7+; TEM (effector memory T cells), CD3+CD45RA−CCR7−; TEMRA (effector T cells), CD3+CD45RA+CCR7−.
CAR-T, chimeric antigen receptor T cells.