Table 2

Immune-related somatic mutations on baseline and relapse biopsy

Sample	Gene name	HGVS	Mutation effect	Tumor alternative allele depth/sequencing depth	Allele frequency
Baseline	MST1	c.1423+1->CC	Splice_Site	18/103	0.17
	PROS1	c.1030A>G	Missense_Mutation	26/132	0.2
	NLGN1	c.1504_1505insC	Frame_Shift_Ins	12/194	0.06
	NLGN1	c.1507delG	Frame_Shift_Del	12/204	0.06
	MUC4	c.5420T>C	Missense_Mutation	29/657	0.04
	TDP2	c.1037G>A	Missense_Mutation	41/155	0.26
	MUC17	c.8179G>A	Missense_Mutation	12/464	0.03
	VWF	c.1060G>A	Missense_Mutation	12/289	0.04
	MAG	c.1388C>T	Missense_Mutation	12/662	0.02
	LILRB2	c.50C>G	Missense_Mutation	12/55	0.22
	PREX1	c.1489G>A	Missense_Mutation	12/381	0.03
Progression	BTN2A1	c.1352G>C	Missense_Mutation	11/92	0.12