Preferred term, n (%) | 1 mg/kg Q2W n=16 | 3 mg/kg Q2W n=15 | 10 mg/kg Q2W n=11 | 3 mg/kg Q4W n=6 | 5 mg/kg Q4W n=10 | All patients N=58 | ||||||
All | Gr 3/4 | All | Gr 3/4 | All | Gr 3/4 | All | Gr 3/4 | All | Gr 3/4 | All | Gr 3/4 | |
Total | 10 (62.5) | 1 (6.3) | 10 (66.7) | 0 | 5 (45.5) | 1 (9.1) | 3 (50.0) | 0 | 6 (60.0) | 0 | 34 (58.6) | 2 (3.4) |
Fatigue | 5 (31.3) | 0 | 2 (13.3) | 0 | 2 (18.2) | 0 | 1 (16.7) | 0 | 3 (30.0) | 0 | 13 (22.4) | 0 |
Diarrhea | 4 (25.0) | 0 | 4 (26.7) | 0 | 1 (9.1) | 0 | 0 | 0 | 1 (10.0) | 0 | 10 (17.2) | 0 |
Pruritus | 3 (18.8) | 0 | 5 (33.3) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 8 (13.8) | 0 |
Hypothyroidism | 2 (12.5) | 0 | 1 (6.7) | 0 | 1 (9.1) | 0 | 0 | 0 | 2 (20.0) | 0 | 6 (10.3) | 0 |
Nausea | 3 (18.8) | 0 | 1 (6.7) | 0 | 1 (9.1) | 0 | 0 | 0 | 1 (10.0) | 0 | 6 (10.3) | 0 |
Decreased appetite | 2 (12.5) | 0 | 0 | 0 | 1 (9.1) | 0 | 0 | 0 | 1 (10.0) | 0 | 4 (6.9) | 0 |
Anemia | 2 (12.5) | 0 | 1 (6.7) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 (5.2) | 0 |
Constipation | 3 (18.8) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 (5.2) | 0 |
Dizziness | 3 (18.8) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 (5.2) | 0 |
Dry mouth | 1 (6.3) | 0 | 1 (6.7) | 0 | 0 | 0 | 0 | 0 | 1 (10.0) | 0 | 3 (5.2) | 0 |
Maculopapular rash | 1 (6.3) | 0 | 2 (13.3) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 (5.2) | 0 |
Vomiting | 2 (12.5) | 0 | 0 | 0 | 1 (9.1) | 0 | 0 | 0 | 0 | 0 | 3 (5.2) | 0 |
Gr, grade; Q2W, once every 2 weeks; Q4W, once every 4 weeks.