Definitions of resistance after discontinuing treatment for metastatic disease
| Stopped therapy (CR/PR/end of study/other social rationale) | Duration of time after last dose of PD-(L)1 inhibitor | Confirmatory scan requirement |
| Primary resistance | No CR/PR prior to discontinuation | No |
| Secondary resistance | Prior CR/PR and ≤12 weeks from last dose | Yes |
| Late progression | Prior CR/PR and >12 weeks from last dose | Yes |
CR, complete response; PD, programmed death; PR, partial response.