Tumor and treatment information.
Identifier | Sarcoma subtype | Prior treatment | Sites of disease | Cell dose (×109) | Vα gene | CDR3 α-chain | Vβ gene | Best tumor response |
Including IFN-γ and low-dose interleukin-2 | ||||||||
IFN#1 | SS | A/I, trabectedin | Soft tissue, lung, brain | 22 | TRAV-8*02 | CALSAVALGMCCI | TRBD1*01 | 32% lung |
IFN#2 | SS | A/I/vincristine, Rtx/Ifos | Lung | 12.9 | TRAV21*01 | CAVMGDNDMRF | TRBV12-3*01 | N/A |
*part of dual alpha, only this alpha sequence was productive based on tetramer staining and functional assays.
IFN#2, second patient; IFN-γ, interferon gamma; IFN#1, first patient; Ifos, ifosfamide; N/A, not applicable; Rtx, rituximab ; SS, synovial sarcoma.