EC20 values and corresponding HEDs of the performed in vitro assays
| Method | EC20 (ng/mL) | Dose (µg)/70 kg patient | Dose (ng)/patient kg |
| Binding to CD3 | 150 | 450 | 6428 |
| Binding to EGFRvIII | 10 307 | 30 921 | 441 728 |
| Cytokine release | |||
| IFN-γ | 42.3 | 127 | 1813 |
| IL-6 | 12.5 | 37.5 | 536 |
| IL-1β | Ambiguous | ||
| MIP-1α | 14.7 | 44.1 | 630 |
| GM-CSF | 27.6 | 82.8 | 1183 |
| TNFα | 16.5 | 49.5 | 707 |
| T cell activation | 1021 | 3063 | 43 757 |
| T cell proliferation | 70.2 | 210 | 3008 |
| Tumor cell cytotoxicity | 1.34 | 4.02 | 57.4 |
EC20, 20% of the maximal effective concentration; EGFRvIII, epidermal growth factor receptor variant III; ; HEDs, human equivalent doses.