Table 1

EC20 values and corresponding HEDs of the performed in vitro assays

MethodEC20 (ng/mL)Dose (µg)/70 kg patientDose (ng)/patient kg
Binding to CD31504506428
Binding to EGFRvIII10 30730 921441 728
Cytokine release
T cell activation1021306343 757
T cell proliferation70.22103008
Tumor cell cytotoxicity1.344.0257.4
  • EC20, 20% of the maximal effective concentration; EGFRvIII, epidermal growth factor receptor variant III; ; HEDs, human equivalent doses.