Table 1

Summary of patient characteristics, cohorts, response data, and TC (N=57)

FeatureCategoryBaseline biopsy specimenOn-treatment biopsy specimen
Low TC
(n=13, 23%)
High TC
(n=44, 77%)
Low TC
(n=15, 26%)
High TC (n=42, 74%)
SexFemale2 (15)24 (55)3 (20)23 (55)
Male11 (85)20 (4512 (80)19 (45)
Age (years)Mean
Range
51
26–80
56
24–86
53
24–78
55.2
24–86
Trial cohortsCarcinoma of unknown primary1 (8)8 (18)2 (13)7 (17)
Skin squamous cell carcinoma3 (25)6 (14)5 (33)4 (10)
Germ cell tumor/testicular tumor2 (17)4 (9)1 (6)5 (12)
Adrenocortical carcinoma0 (0)5 (11)0 (0)5 (12)
Paraganglioma/pheochromocytoma1 (8)4 (9)2 (13)3 (7)
Small cell malignancies of non-pulmonary origin1 (8)3 (7)1 (6)3 (7)
Medullary renal cell carcinoma1 (8)1 (2)1 (6)1 (2)
Penile carcinoma0 (0)1 (2)0 (0)1 (2)
Vascular sarcoma1 (8)0 (0)1 (6)0 (0)
Other rare tumors3 (25)12 (27)2 (6)13 (31)
ResponseCR0 (0)0 (0)0 (0)0 (0)
PR0 (0)6 (14)3 (2)3 (7)
SD (≥6 months)0 (0)7 (16)3 (2)5 (12)
SD (<6 months)3 (25)2 (5)2 (1)2 (5)
PD10 (83)29 (66)7 (47)32 (76)
Clinical benefit rate (PR or SD >6 months)1 (8)13 (30)6 (40)8 (19)
  • CR, complete response; PD, progressive disease; PR, partial response; SD, stable disease; TC, tumor content.