Table 1

Potency of STAT5 activation for ALKS 4230 and rhIL-2 on selected human and mouse lymphocyte populations

Lymphocyte population	Human		Mouse
Lymphocyte population	ALKS 4230 EC₅₀ (nM)*	rhIL-2 EC₅₀ (nM)†	ALKS 4230 EC₅₀ (nM)†	rhIL-2 EC₅₀ (nM)†
NK cells	0.45±0.09	1.6	9.5	12.0
Memory-phenotype CD8⁺ T cells			12.6	7.8
Naïve CD8⁺ T cells	2.2±1.0	1.1
Central/Transitional memory CD8⁺ T cells	1.1±0.1	2.0
Effector memory CD8⁺ T cells	1.25±0.4	1.8
Terminal effector CD8⁺ T cells	0.93±0.3	1.0
CD4⁺ T_regs	0.59±0.2	0.0015	12.0	0.011

*Data was generated from three separate experiments, each performed in three replicates, and the error represents SD.
†Data was generated from one experiment performed in three replicates.
IL-2, interleukin-2; NK, natural killer; rhIL-2, recombinant human IL-2; T_regs, regulatory T cells.