Table 1

Surface expression, % positive cells (mean fluorescent intensity)

A. Tumor cells
Tumor% O2 Viability (%)HLA-ABCMICA/BB7-H6CD112CD155PD-L1EGFR
PC32097.594.5 (135)28.8 (42)2.6 (38)9.1 (50)97.1 (410)93.1 (56)97.0 (98)
097.195.6 (141)42.2 (45)2.4 (63)9.6 (42)98.7 (425)88.0 (50)94.2 (57)
MCF-72093.560.0 (63)47.9 (55)2.9 (42)15.1 (48)96.9 (154)39.0 (101)63.0 (52)
092.650.9 (59)49.9 (57)2.5 (44)24.9 (43)96.5 (152)43.1 (144)60.1 (13)
H4602098.795.9 (115)4.7 (23)6.9 (20)3.6 (27)99.1 (226)91.2 (47)94.9 (44)
098.294.2 (108)5.6 (27)12.1 (24)3.3 (26)99.6 (233)96.4 (41)92.6 (49)
B. NK cells
NK cells% O2 Viability (%)NKG2DCD16NKp44NKp46DNAM-1GranzymePerforin
HD8972089.732.6 (440)55.2 (82)13.7 (95.5)58.6 (126)19.0 (69)69.3 (1946)17.4 (489)
087.6 25.0 (337)63.8 (74) 10.1 (141)47.8 (97.3)23.7 (70)77.1 (1781) 3.6 (764)
HD8362093.215.5 (690)69.5 (236)20.3 (207)39.0 (117)19.3 (215)99.0 (2716)94.7 (1119)
091.5 9.9 (561) 45.5 (162) 2.1 (84) 35.2 (84.0) 12.1 (103) 80.4 (2665) 14.5 (309)
HD9502091.19.2 (511)68.9 (339)25.4 (274)53.0 (177)22.7 (119)91.5 (1101)64.2 (276)
090.6 6.2 (458) 53.6 (193) 2.1 (119) 46.5 (132) 8.5 (160)85.8 (787) 51.4 (220)
haNK2090.722.1 (229)58.7 (433)2.5 (122)3.1 (274)59.3 (169)99.2 (455)55.6 (373)
090.517.7 (208)54.7 (403) 1.8 (124) 3.4 (183)67.3 (200)98.4 (486)60.3 (629)
  • Bold type indicates marked modulation (≥20% change in % positive cells or ≥50% change not observed in isotype control).

  • haNK, high affinity NK; NK, natural killer; PD-L1, programmed death-ligand 1.