Multivariable Cox proportional-hazards analysis of associations of clinicopathologic and treatment characteristics with postoperative overall survival in the historical MDACC cohort (n=1524)
| Variable | HR | 95% CI | P value |
| Neutrophil count, absolute (103 cells/µL) | 1.82 | 1.24 to 2.68 | 0.002 |
| Lymphocyte count, absolute (103 cells/µL) | 1.50 | 0.91 to 2.48 | 0.114 |
| Age, years | 1.03 | 1.02 to 1.04 | <0.001 |
| Coronary artery disease | 1.30 | 1.02 to 1.65 | 0.036 |
| Hypertension | 1.22 | 1.02 to 1.47 | 0.034 |
| Smoking | |||
| Never | Reference | ||
| Former/current | 1.42 | 1.07 to 1.87 | 0.014 |
| Zubrod Performance Status | |||
| 0 | Reference | ||
| 1–2 | 1.31 | 1.09 to 1.58 | 0.004 |
| ASA Classification | |||
| 1–3 | Reference | ||
| 4 | 2.19 | 1.18 to 4.06 | 0.013 |
| Histology | |||
| Adenocarcinoma | Reference | ||
| Squamous cell carcinoma | 0.99 | 0.80 to 1.22 | 0.922 |
| Other | 1.19 | 0.86 to 1.64 | 0.306 |
| Differentiation | |||
| Low | 1.36 | 1.12 to 1.65 | 0.002 |
| Moderate | Reference | ||
| High | 0.55 | 0.41 to 0.74 | <0.001 |
| Extent of resection | |||
| Sublobar/lobectomy | Reference | ||
| Pneumonectomy | 1.54 | 1.04 to 2.29 | 0.031 |
| Pathologic stage | |||
| I | Reference | ||
| II | 1.74 | 1.41 to 2.15 | <0.001 |
| III–IV | 2.14 | 1.65 to 2.77 | <0.001 |
| Pathologic margin | |||
| R0/R1 | Reference | ||
| R2 | 0.35 | 0.14 to 0.85 | 0.021 |
| Adjuvant radiotherapy | 1.36 | 1.03 to 1.80 | 0.029 |
| Neutrophil count×lymphocyte count, interaction | 0.77 | 0.62 to 0.96 | 0.021 |
Other variables tested include diabetes mellitus, congestive heart failure, alcohol use, operative approach (thoracoscopic vs thoracotomy), and adjuvant chemotherapy.