Table 2

Associations between T-cell counts and T-cell repertoire

Population	TCR index	mCRPC		Melanoma
Population	TCR index	Correlation	P value	Correlation	P value
CD8+count at baseline	Clonality at baseline	0.71	0.003	0.81	<0.001
CD8+count at baseline	Relative clonality	−0.59	0.022	−0.82	<0.001
CD8+count at baseline	Proportion of increase clones	0.13	0.648	0.58	0.029
CD8+count at baseline	Proportion of decrease clones	−0.57	0.026	−0.54	0.045
CD8+ratio	Relative clonality	0.50	0.170	0.55	0.041
CD8+ratio	Proportion of increase clones	−0.22	0.576	−0.69	0.007
CD8+ratio	Proportion of decrease clones	0.23	0.546	0.61	0.020
CD4+count at baseline	Clonality at baseline	0.34	0.216	0.28	0.326
CD4+count at baseline	Relative clonality	−0.53	0.038	−0.29	0.311
CD4+count at baseline	Proportion of increase clones	0.37	0.173	0.34	0.233
CD4+count at baseline	Proportion of decrease clones	−0.38	0.160	−0.34	0.220
CD4+ratio	Relative clonality	0.13	0.732	0.24	0.418
CD4+ratio	Proportion of increase clones	0.07	0.864	−0.28	0.326
CD4+ratio	Proportion of decrease clones	0.63	0.067	0.24	0.409

CD8+ and CD4+ count ratios were calculated as the count in the corresponding population at on-treatment divided by that at baseline.
p<0.05 denoted in bold.
mCRPC, metastatic castration resistant prostate cancer; TCR, T-cell receptors.