Adverse events that arose in at least three patients
| Adverse event | All, n (%) | Grade 3/4, n (%) |
| Sum of all | 43 (100.0) | 30 (69.8) |
| Wound dehiscence | 11 (25.6) | 6 (14.0) |
| ALP increased | 31 (72.1) | 4 (9.3) |
| Blood bilirubin increased | 22 (51.2) | 4 (9.3) |
| Hypertriglyceridemia | 32 (74.4) | 3 (7.0) |
| Anorexia | 20 (46.5) | 3 (7.0) |
| Weight loss | 15 (34.9) | 3 (7.0) |
| Pneumothorax | 9 (20.9) | 3 (7.0) |
| Platelet count decreased | 30 (69.8) | 2 (4.7) |
| Diarrhea | 21 (48.8) | 2 (4.7) |
| Hand-foot syndrome | 21 (48.8) | 2 (4.7) |
| Pain in extremity | 20 (46.5) | 2 (4.7) |
| AST increased | 18 (41.9) | 2 (4.7) |
| ALT increased | 17 (39.5) | 2 (4.7) |
| Leukopenia | 16 (37.2) | 2 (4.7) |
| Rash | 14 (32.6) | 2 (4.7) |
| Mucositis oral | 11 (25.6) | 2 (4.7) |
| Hypertension | 10 (23.3) | 2 (4.7) |
| Abdominal pain | 8 (18.6) | 2 (4.7) |
| Toothache | 6 (14.0) | 2 (4.7) |
| Non-cardiac chest pain | 2 (4.7) | 2 (4.7) |
| Hypothyroidism | 35 (81.4) | 1 (2.3) |
| Blood LDH increased | 27 (62.8) | 1 (2.3) |
| Proteinuria | 11 (25.6) | 1 (2.3) |
| Cough | 10 (23.3) | 1 (2.3) |
| Nausea | 8 (18.6) | 1 (2.3) |
| Vomiting | 6 (14.0) | 1 (2.3) |
| Hemorrhoidal hemorrhage | 6 (14.0) | 1 (2.3) |
| Hair color changes | 5 (11.6) | 0 (0.0) |
| Fatigue | 4 (9.3) | 1 (2.3) |
| Peripheral neuroinflammation | 3 (7.0) | 1 (2.3) |
ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; LDH, lactate dehydrogenase.