Differential diagnosis of CRS6
| Familial HLH | Secondary HLH/MAS | CRS related to HLH or MAS | Sepsis | |
| Genetics | Homozygous mutation | Heterozygous mutations in case-reports | Not reported | Not reported |
| Biomarkers | ||||
| IL-10 | Very high | Very high | High | High |
| IFN-alpha | Very high | Very high | Very high | Normal |
| IL-6 | High | High | Very high | Very high |
| Ferritin | Very high | Very high | Very high | High |
| CD 163 | Very high | Very high | High | Not reported |
CRS, cytokine release syndrome; HLH, hemophagocytic lymphohistiocytosis; IFN, interferon; IL-6, interleukin-6; MAS, macrophage activation syndrome.