Table 1

Cytokines elevated in CRS

CytokineMolecular weight (kDa)
Interleukin-6 (IL-6)26Proinflammatory
IL-1018Anti-inflammatory
Interferon-gamma35Proinflammatory
Tumor necrosis factor-α monomer17Proinflammatory
IL-1β17Proinflammatory
IL-217Proinflammatory
IL-2 receptorProinflammatory
IL-8, MCP-1, and MIP-1bIL-8–8 kDaReported in patients treated with CART-19 and blinatumomab

  • CART, chimeric antigen receptor T cells; CRS, cytokine release syndrome.