Table 3

Treatment-related adverse events (N=27)

ToxicityGrade 1, n (%)Grade 2, n (%)Grade 3, n (%)Grade 4, n (%)All, n (%)
Cardiovascular
 Edema limbs1 (4)0 (0)0 (0)0 (0)1 (4)
 Hypertension0 (0)0 (0)1 (4)0 (0)1 (4)
Dermatologic
 Dry skin1 (4)0 (0)0 (0)0 (0)1 (4)
 Injection site reaction11 (41)0 (0)0 (0)0 (0)11 (41)
 Pruritus2 (7)1 (4)0 (0)0 (0)3 (11)
 Rash6 (22)1 (4)0 (0)0 (0)7 (26)
Endocrine
 Hyperglycemia0 (0)0 (0)1 (4)0 (0)1 (4)
 Hyperthyroidism2 (7)0 (0)0 (0)0 (0)2 (7)
 Hypothyroidism0 (0)1 (4)0 (0)0 (0)1 (4)
Gastrointestinal
 Abdominal pain1 (4)0 (0)0 (0)0 (0)1 (4)
 Anorexia2 (7)0 (0)0 (0)0 (0)2 (7)
 Constipation1 (4)0 (0)0 (0)0 (0)1 (4)
 Diarrhea1 (4)2 (7)0 (0)0 (0)3 (11)
 Dry mouth1 (4)0 (0)0 (0)0 (0)1 (4)
 Dysgeusia1 (4)0 (0)0 (0)0 (0)1 (4)
 Esophageal pain1 (4)0 (0)0 (0)0 (0)1 (4)
 Gastroesophageal reflux disease2 (7)1 (4)0 (0)0 (0)3 (11)
 Lipase increased1 (4)1 (4)0 (0)0 (0)2 (7)
 Nausea8 (30)0 (0)0 (0)0 (0)8 (30)
 Serum amylase increased1 (4)1 (4)1 (4)0 (0)3 (11)
 Vomiting1 (4)0 (0)0 (0)0 (0)1 (4)
General
 Allergic reaction0 (0)1 (4)0 (0)0 (0)1 (4)
 Fatigue5 (19)1 (4)1 (4)0 (0)7 (26)
 Fever1 (4)0 (0)0 (0)0 (0)1 (4)
 Malaise1 (4)0 (0)0 (0)0 (0)1 (4)
Hematologic
 Platelet count decreased0 (0)0 (0)0 (0)1 (4)1 (4)
Infections and infestations
 Periorbital infection0 (0)1 (4)0 (0)0 (0)1 (4)
Musculoskeletal
 Arthralgia1 (4)1 (4)0 (0)0 (0)2 (7)
 Bone pain1 (4)0 (0)0 (0)0 (0)1 (4)
 Myalgia3 (11)0 (0)0 (0)0 (0)3 (11)
Neurologic/psychiatric
 Dizziness1 (4)0 (0)0 (0)0 (0)1 (4)
Respiratory
 Cough1 (4)0 (0)0 (0)0 (0)1 (4)
 Dyspnea4 (15)1 (4)0 (0)0 (0)5 (19)