Table 1

Correlation between tumor cell HLA antigen expression scores and T-cell density in melanoma metastases

	Correlation with CD8⁺ cell density		Correlation with CD45RO⁺ cell density		Correlation with PD-1⁺ cell density
	r	P value	r	P value	r	P value
Lymph node metastases (n=50)
HC10	0.4493	<0.001	0.3913	<0.01	0.4111	<0.01
HCA2*	0.5092	<0.001	0.3542	<0.05	0.5121	<0.001
EMR8-5	0.3710	<0.01	0.3427	<0.02	0.3453	<0.02
Anti-β2M	0.3339	<0.02	0.3204	<0.05	0.3145	<0.05
Anti-HLA-DR, DQ, DP	0.4251	<0.01	0.3021	<0.05	0.4335	<0.01
Cutaneous/subcutaneous metastases (n=35)
HC10	−0.0523	NS	−0.0698	NS	−0.1869	NS
HCA2	0.1724	NS	0.1619	NS	0.0612	NS
EMR8-5	−0.1794	NS	−0.2340	NS	−0.1674	NS
Anti-β2M	−0.0299	NS	−0.0205	NS	−0.1067	NS
Anti-HLA-DR, DQ, DP	0.6440	<0.001	0.3734	<0.05	0.5217	<0.001

Significant correlations are shown in bold.
*There were two patients (12 lymph node metastases) where HCA2 could not be evaluated because of negativity of normal cells.
CD, cluster of differentiation; HLA, human leukocyte antigen; β2M, β2-microglobulin; NS, not significant; PD-1, programmed cell death protein 1; r, Pearson correlation coefficient.