NOD SCID KD (M x10-6) | SCID KD (M x10-6) | |
Aggregated hIgG | 0.13 | 0.15 |
Cetux hIgG1 | 4.38 | 5.42 |
Ritux hIgG1 | 2.50 | 3.18 |
Ritux hIgG2 | 4.82 | 4.65 |
Ritux mIgG1 | 2.25 | 2.02 |
Ritux mIgG2a | 2.43 | 2.63 |
Recombinant mFcγRII extracellular domains from SCID or NOD SCID mice were captured on a Biacore CM5 chip using an immobilized anti-HIS antibody. IgG of specific isotypes or heat aggregated, pooled hIgG was flowed over the chip and the KD value calculated using Biacore evaluation software.
FcγR, Fcγ receptors; NOD, non-obese diabetic; SCID, severe combined immunodeficient.