Table 1

Patients’ characteristics

Overall cohortDeleterious DDRWild type/VUS DDR
No of patients229 (100%)43 (19%)186 (81%)
Age at diagnosis (years), median (range)60 (33–84)61 (33–74)60 (37–84)
Gender (male)168 (73%)32 (74%)136 (73%)
Nephrectomy218 (95%)41 (95%)177 (95%)
Histology
 Clear cell RCC229 (100%)43 (100%)186 (100%)
Denovo metastatic85 (37%)19 (44%)66 (35%)
IMDC risk score*
 Favorable74 (34%)15 (39%)59 (34%)
 Intermediate113 (53%)20 (51%)93 (53%)
 Poor27 (13%)4 (10%)23 (13%)
No of deleterious DDR alterations (somatic and germline)48480
 Somatic alterations35 (73%)35 (73%)0
 Germline alterations13 (27%)13 (27%)0
  • *Missing for 15 patients.

  • DDR, DNA damage repair; IMDC, International Metastatic Renal Cell Carcinoma Database Consortium; RCC, renal cell carcinoma; VUS, variants of unknown significance.