Table 3

Top 20 significantly perturbed median spatial relationships in PCa tissue in response to HDRBT

TargetNeighborANOVA p value
CD8+T cellsCD8+T cells 0.00097
T cells DC 0.0048
DC 0.0072
DNT cells Tregs 0.018
B cells DC PDL1+ 0.04
CD4+T cellsCD8+T cells 0.04
HMWCK-PDL1+ CD8+T cells 0.046
T cells 0.056
DNT cells CD8+T cells0.06
T cells DC PDL1+0.081
HMWCK-PDL1+ Tregs0.095
CD8+T cellsHMWCK-PDL1+0.1
DC PDL1+0.11
HMWCK+PDL1- CD8+T cells0.11
CD4+T cellsCD4+T cells0.14
Tregs CD8+T cells0.16
HMWCK-PDL1+ CD4+T cells0.16
B cells DC0.17
CD4+T cellsHMWCK-PDL1+0.18
DNT cells HMWCK-PDL1+0.22
  • HDRBT, high dose-rate brachytherapy; PCa, prostate cancer.