Nephrologist-confirmed ICPi nephrotoxicity
| Age | Sex | Cancer | ICPi duration | Comorbidities | Other drugs | Baseline sCr mg/dL (umol/L) | Peak sCr mg/dL (umol/L) | Other IRAE | Urine protein | Urine WBC | Diagnosis/ biopsy result | Treatment | Renal outcome |
| 63 | F | Melanoma | 20 days | None | – | 1.2 (105) | 1.7 (147) | Yes | 3 mg/dL | 125 cel/uL | AIN | Stopping ICI | Non-recovery |
| 68 | M | Melanoma | 30 days | Hypertension | PPI; diuretics | 1.2 (102) | 6.9 (609) | Yes | 3 mg/dL | 125 cel/uL | AIN | Stopping ICPi+corticosteroids | Non-recovery |
| 69 | M | Melanoma | 83 days | Hypertension | ACEi/ARB; PPI; NSAIDs diuretics | 1.1 (97) | 2.4 (214) | Yes | 3 mg/dL | 10 cel/uL+casts | AIN | Stopping ICPi+corticosteroids | Full recovery |
| 76 | M | Melanoma | 83 days | None | 0.9 (81) | 1.7 (147) | Yes | 3 mg/dL | 0 | AIN | Stopping ICPi | Partial recovery | |
| 66 | M | Melanoma | 30 days | Hypertension, ischemic cardiomyopathy | ACEi/ARB; PPI; NSAIDs | 1.1 (95) | 3.9 (341) | Yes | – | – | AIN | Stopping ICPi+corticosteroids | Full recovery |
| 42 | M | Lymphoma | 35 days | Hypertension | – | 0.8 (74) | 4.8 (427) | No | 5.86 g/24 hours | 0 | MCD+ATN | Stopping ICPi+corticosteroids | Partial recovery |
| 55 | M | Melanoma | 181 days | Hypertension | – | 0.9 (79) | 1.7 (147) | Yes | 10 mg/dL | 0 | TMA | Stopping ICPi+corticosteroids | Partial recovery |
| 56 | F | Melanoma | 104 days | Ischemic cardiomyopathy | ACEi/ARB | 0.7 (66) | 3.5 (306) | Yes | 10 mg/dL | 0 | TMA | Stopping ICPi+corticosteroids | Partial recovery |
| 45 | M | Melanoma | 55 days | Type 2 diabetes | – | 0.7 (61) | 0.9 (79) | No | 9 g/24 hours | – | MCD | Stopping ICPi+corticosteroids | Full recovery |
| 53 | F | Ovary | 64 days | None | – | 0.7 (67) | 0.9 (81) | No | 12 g/24 hours | – | Membranous nephropathy | Stopping ICPi+corticosteroids | Full recovery |
| 39 | M | Colon | 61 days | None | – | 0.9 (80) | 1.2 (109) | No | 2.2 g/24 hours | – | Membranous nephropathy | Stopping ICPi+corticosteroids | Full recovery |
| 72 | F | Ovary | 64 days | Hypertension | ACEi/ARB; PPI | 1.2 (106) | 2.1 (186) | No | – | 70 cel/uL | AIN | Stopping ICPi+corticosteroids | Partial recovery |
ACEi, angiotensin-converting enzyme inhibitors; AIN, acute interstitial nephritis; ARB, angiotensin-receptor blockers; ATN, acute tubular necrosis; ICPi, immune checkpoint inhibitors; IRAE, Immune-related adverse event; MCD, minimal change disease; NSAIDs, non-steroidal anti-inflammatory drugs; PPI, proton pump inhibitors; TMA, thrombotic microangiopathy; WBC, white blood cell count.