Characteristics of AKI events
| AKI (any stage) (%) | 51 (16.5) |
| AKI stage 1 | 27 (53) |
| AKI stage 2 | 11 (22) |
| AKI stage 3 | 13 (25) |
| Receipt of renal replacement therapy | 1 (1.9) |
| Sustained AKI (ie, elevation ≥1.5 times baseline sCr for ≥72 hours) (%) | 44 (86) |
| Non-sustained AKI (ie, elevation ≥1.5 times baseline sCr for <72 hours) (%) | 7 (14) |
| Biopsy- or nephrologist-confirmed nephrotoxicity (%) | 12 (24) |
| Patients with AKI who received ICPi re-challenge (%) | 12 (24) |
| Patients who developed AKI after re-challenge (%) | 1 (8.3) |
| Presumptive AKI etiologies among patients with sustained AKI (%) | |
| Biopsy- or nephrologist-confirmed sustained AKI | 12 (27) |
| Possible ICPi-related AKI | 18 (41) |
| AKI likely related to other causes (eg, pre-renal/hemodynamic, sepsis-related or obstructive AKI) | 14 (32) |
AKI, acute kidney injury; ICPi, immune checkpoint inhibitors; sCr, serum creatinine.