Variable | Univariate analysis | Multivariate analysis | ||||
HR | 95% CI | P value | HR | 95% CI | P value | |
GMS (high vs low) | 0.29 | 0.18 to 0.45 | <0.001 | 0.30 | 0.19 to 0.49 | <0.001 |
TMB (high vs low) | 0.43 | 0.30 to 0.63 | <0.001 | |||
PD-L1 (≥1% vs <1%) | 0.53 | 0.36 to 0.76 | 0.001 | 0.64 | 0.44 to 0.93 | 0.020 |
Gender (male vs female) | 0.92 | 0.60 to 1.40 | 0.691 | |||
Age (≥65 vs <65 years) | 1.07 | 0.75 to 1.52 | 0.721 | |||
Smoking (ever vs never) | 0.56 | 0.37 to 0.84 | 0.006 |
The p values in bold were statistically significant.
CI, confidence interval; GMS, genomic mutation signature; HR, hazard ratio; PD-L1, programmed cell death ligand 1; TMB, tumor mutation burden.