Herpes viruses | |||||||||
α-subfamily | β-subfamily | γ-subfamily | |||||||
HSV-1 | HSV-2 | VZV | CMV | HHV-6A | HHV-6B | HHV-7 | EBV | KSHV | |
Downregulation of proinflammatory cytokines/chemokines by viral protein/peptide and viral miR | IL-6, IL-12, IL-23, TNF-α, IFN-α, IFN-β, CCL5 (Rantes) by VP16, ICP4, ICP27107 | n.d. | n.d. | IFN-α and IFN-β by US9114; TNF-α and IFN-γ by UL23115 116; CCCL5 (Rantes) by UL21.5 and US28118 119 | n.d. | n.d. | n.d. | IFN-γ by BZLF1108; IFN-β by Zta109; TNF-α by LMP1110; IL-1 by miR-BHRF1-2-5p112 | TNF-α and IL-1112 |
CMV, cytomegalovirus; EBV, Epstein-Barr virus; HSV, herpes simplex virus; IFN, interferon; IL, interleukin; KSHV, Kaposi-Sarkom herpes virus; miR, microRNA; n.d., not determined; TGF, transforming growth factor; VZV, varicella-zoster virus.