Viral peptides/proteins as well as viral miRs and other mechanisms leading to downregulation of the NKG2D ligands
| NKG2D ligands | ||||||||
| MICA | MICB | ULBP1 | ULBP2 | ULBP3 | ULBP4 | ULBP5 | ULBP6 | |
| Viral proteins/peptides | UL142 (CMV92) US18 (CMV94) US20 (CMV94) U21 (HHV-795) K5 (KSHV96) | UL-16 (CMV91) U21 (HHV-795) K5 (KSHV96) | UL-16 (CMV90) U21 (HHV-795) | UL-16 (CMV90) | UL142 (CMV93) | n.d. | UL-16 (CMV90) | UL-16 (CMV90) |
| viral miRs | miR-BART7 (EBV100) | miR-BART2-5p (EBV99) miR-UL122 (CMV101) miR-K12-7 (KSHV99) | n.d. | miR-H8 (HSV-198) | miR-H8 (HSV-198) | n.d. | n.d. | n.d. |
| Downregulation on unspecified mechanism | HSV-187; EBV89 | EBV89 | HSV-188 | HSV-187; VZV88 | HSV-188; VZV88 | EBV89 | n.d. | n.d. |
CMV, cytomegalovirus; EBV, Epstein-Barr virus; HSV-1, herpes simplex virus 1; KSHV, Kaposi-Sarkom herpes virus; miRs, microRNAs; n.d., not determined; VZV, varicella-zoster virus.