Clinical and pathological characteristics of HNSCC patients in TCGA cohort and TMA cohort
| Characteristics | TCGA cohorts (n=416) | Tissue array cohorts (n=115) | P value |
| Age | |||
| ≤40 | 17 (4.1%) | 1 (0.9%) | 0.029 |
| 40–60 | 184 (44.2%) | 40 (34.8%) | |
| ＞60 | 215 (51.7%) | 74 (64.3%) | |
| Sex | |||
| Male | 302 (72.6%) | 85 (73.9%) | 0.779 |
| Female | 114 (27.4%) | 30 (26.1%) | |
| Tumor location | |||
| Oral cavity | 287 (68.9%) | 55 (47.8%) | <0.001 |
| Oropharynx | 26 (6.3%) | 4 (3.5%) | |
| Larynx | 103 (24.8%) | 56 (48.7%) | |
| Tumor grade | |||
| G1 | 54 (13.0%) | 40 (34.8%) | <0.001 |
| G2 | 250 (60.1%) | 61 (53.0%) | |
| G3 | 96 (23.1%) | 14 (12.2%) | |
| G4 | 1 (0.2%) | 0 | |
| Gx | 15 (3.6%) | 0 | |
| Path_T stage | |||
| T1 | 40 (9.6%) | 44 (38.3%) | <0.001 |
| T2 | 120 (28.8%) | 36 (31.3%) | |
| T3 | 92 (22.1%) | 15 (13.0%) | |
| T4 | 164 (39.4%) | 20 (17.4%) | |
| Path_N stage | |||
| N0 | 158 (38.0%) | 84 (73.0%) | <0.001 |
| N1 | 63 (15.1%) | 15 (13.0%) | |
| N2 | 157 (37.7%) | 16 (13.9%) | |
| N3 | 6 (1.4%) | 0 | |
| NX | 32 (7.7%) | 0 | |
| TNM stage | |||
| I | 23 (5.5%) | 40 (34.8%) | <0.001 |
| II | 69 (16.6%) | 28 (24.3%) | |
| III | 75 (18.0%) | 19 (16.5%) | |
| IV | 249 (59.9%) | 28 (24.3%) |
HNSCC, head and neck squamous cell carcinoma; TCGA, The Cancer Genome Atlas; TMA, tissue microarrays; TNM, tumor, node, metastasis.