Patient 1 | Patient 2 | Patient 3 | Patient 4 | Patient 5 | Patient 6 | Patient 7 | |
Severity grade of meningitis | 3 | 2 | 1 | 2 | 1 | 2 | 1 |
Symptoms | Fever, confusion, partial seizure. | Headache, nausea, photophobia. | Headache, four limbs pain. | Headache, vomiting. | Headache, vomiting. | Headache, fever. | Fever, headache |
Lumbar puncture | |||||||
cells/mm3 | 40 (90% L) | 8 (100% L) | 19 (90% L) | 25 (90% L) | 0 | 9 (90% L) | 320 (90% L) |
Protein level | 0.99 g/L | 0.30 g/L | 0.39 g/L | 0.43 g/L | 0.59 g/L | 0.54 g/L | <0.45 g/L |
Steroid treatment* | |||||||
Initial dose | 1 mg/kg/day | 1 mg/kg/day | 0 | 1 mg/kg/day | 0 | 1 mg/kg | 0 |
Length at full dose | 7 days | 7 days | 7 days | 14 days | |||
Length of tapering | 42 days | 42 days | 42 days | 42 days | |||
Delay of complete recovery | |||||||
From irAE-N onset | 18 days | 17 days | 10 days | 21 days | 65 days | 49 days | 10 days |
From steroids onset | 2 days | 14 days | – | 2 days | – | 14 days | – |
Other irAEs occurrence | None | None | None | Hypophysitis (gr. 2), diabetes (gr. 2), hepatitis (gr. 1) | None | Hypophysitis (gr. 2), hepatitis (gr. 4), colitis (gr. 2) small fibers neuropathy (gr.1) | None |
*Prednisone equivalent doses.
irAE, immune-related adverse event; irAE-N, neurological immune-related adverse event; L, lymphocytes.