Table 2

Single-nucleotide polymorphisms (SNPs) associated with recurrence and survival in patients with early-stage non-small cell lung cancer

Gene-SNP by outcomeLocationModelDiscoveryValidationMeta-analysis*P_het
HR (95% CI)†P valueHR (95% CI)†P valueHR (95% CI)†P value
Recurrence
TRB: rs1964986‡IntronREC1.56 (1.04 to 2.34)2.99E-022.36 (1.44 to 3.85)6.00E-041.84 (1.35 to 2.52)1.15E-040.20
IL2RB: rs3218339IntronDOM1.53 (1.08 to 2.18)1.75E-021.91 (1.23 to 2.96)3.93E-031.67 (1.27 to 2.20)2.55E-040.45
SYK: rs10761395IntronREC1.81 (1.17 to 2.82)8.01E-031.86 (1.06 to 3.26)2.95E-021.83 (1.30 to 2.59)6.03E-040.94
TRA: rs7155927IntronDOM0.58 (0.37 to 0.92)2.13E-020.52 (0.30 to 0.91)2.12E-020.56 (0.39 to 0.79)1.18E-030.75
CD4: rs3782736‡IntronREC0.62 (0.42 to 0.92)1.79E-020.54 (0.32 to 0.93)2.49E-020.59 (0.43 to 0.81)1.20E-030.71
TRB: rs1573618‡IntronADD0.80 (0.64 to 1.00)4.65E-020.73 (0.55 to 0.98)3.84E-020.77 (0.65 to 0.92)4.52E-030.66
PDCD1LG2: rs7854413‡missenseDOM0.64 (0.40 to 1.00)4.91E-020.50 (0.27 to 0.95)3.38E-020.59 (0.41 to 0.85)4.61E-030.56
Survival
IDO1: rs10108662‡IntronREC1.49 (1.01 to 2.21)4.49E-022.47 (1.60 to 3.80)3.98E-051.87 (1.40 to 2.51)2.17E-050.09
CUL1: rs122571IntronADD0.79 (0.65 to 0.96)1.71E-020.66 (0.51 to 0.86)1.79E-030.74 (0.63 to 0.87)1.61E-040.27
GRB2: rs959260IntronDOM1.39 (1.05 to 1.84)2.11E-021.79 (1.24 to 2.60)2.00E-031.52 (1.22 to 1.90)2.13E-040.28
CUL1: rs243538‡IntronADD0.75 (0.61 to 0.93)7.54E-030.74 (0.56 to 0.98)3.30E-020.75 (0.63 to 0.88)6.32E-040.94
GRB2: rs4789182‡IntronDOM1.31 (1.00 to 1.72)4.50E-021.67 (1.16 to 2.41)5.00E-031.43 (1.15 to 1.77)1.13E-030.29
TRB: rs1573618‡IntronADD0.82 (0.68 to 0.99)4.26E-020.71 (0.54 to 0.93)1.38E-020.79 (0.67 to 0.92)2.14E-030.39
JAK1: rs4915675IntronREC1.67 (1.02 to 2.72)4.02E-021.91 (1.07 to 3.43)2.94E-021.91 (1.07 to 3.43)2.96E-030.73
  • *The meta-analysis was based on a fixed-effects model.

  • †HR was adjusted for age, gender, smoking status, tumor stage, performance status and treatment.

  • ‡Data for rs2855983 and rs10975179 were not shown owing to their strong linkage with rs1964986 and rs7854413 (r2 >0.8), respectively. In the validation phase, data for rs1964986, rs3782736, rs1573618, rs10108662, rs243538, and rs4789182 were replaced by linked SNPs (r2 >0.8) rs10273639, rs10849524, rs6464489, rs7820268, rs243519, and rs9944529, respectively.

  • ADD, additive; DOM, dominant; P het, p test for heterogeneity; REC, recessive.