Grade* | Adverse event |
1 | Abdominal distension |
1 | ↑Alkaline phosphatase |
1 | ↑ALT |
1 | ↑aPTT |
1 | ↑AST |
1 | Chills |
3 | Dehydration |
2 | Diarrhea |
1 | Edema (LE) |
2 | Fatigue† |
3 | Fever† |
2 | Hyperbilirubinemia |
3 | Hyperglycemia |
3 | Hypertension |
2 | Hypoalbuminemia |
3 | Hypokalemia |
1 | Hypomagnesemia |
3 | Hyponatremia |
3 | Hypophosphatemia |
2 | Hypotension |
1 | ↑INR |
2 | Pulmonary edema |
2 | Rigors |
1 | Tachycardia |
1 | Thrombocytopenia |
*Highest grade experienced for each event noted.
†Led to 25% IL-2 dose reduction.
ALT, alanine aminotransferase; aPTT, activated partial thromboplastin time; AST, aspartate aminotransferase; IL-2, interleukin-2; INR, international normalized ratio.