Table 1

Laboratory work-up

General laboratory testing (normal values)Results
CRP (<10 mg/L)15
Vitamin B12 (145–569 pmol/L)1316
TSH (0.27–4.2 mUI/L)1,82
Serum albumin (35–52 g/L)34.8
CSF testing (normal values)  
Total protein (150–450 mg/L)2551
Albumin (80–300 mg/L)1443
Glucose (2.4–4.4 mmol/L)4
LDH (<40 U/L)24
Albumin quotient (CSF/blood, <8×103)41.5
Protein electrophoresisIntrathecal oligoclonal IgG pattern
Bacterial PCR (Neisseria meningitidis, Listeria monocytogenes, Streptococcus pneumoniae, Haemophilus influenza)Negative
Viral PCR (HSV-1, HSV-2, VZV, CMV, EBV)Negative
Tumorous cytologyNegative
CMV PCR values (copies/mL)  
Day 30 post-TIL-ACT2600
Day 36 post-TIL-ACT9320
Day 41 post TIL-ACT2950
Day 48 post-TIL-ACT556
Serologies  
CMV, EBV, HSV and VZVIgM negative
IgG positive
HIV, viral hepatitis (B, C and E)Negative
Autoimmune laboratory analysis  

  • Rheumatoid factor.

  • Antineutrophil cytoplasmic antibodies (ANCAs, such as PR3 and MPO).

  • Antinuclear antibodies (including SSA, SSB, RNP, Sm, Scl70, and Jo1).

Negative
IgM antibodies against myelin-associated glycoproteinNegative
Antibodies against gangliosides

  • Gq1b.

  • Leucin-rich glioma inactivated 1.

  • Contacting associated protein 2.

  • N-methyl-D-aspartate receptor.

  • Aquaporin 4.

Negative
Antibodies against myelin oligodendrocyte glycoproteinNegative
Antibodies against the node of Ranvier

  • Antineurofascin 155 and 186.

  • Anticontactin.

  • Anti-Caspr1.

Negative
Antibody against the antifibroblast growth factor receptor 3Negative
Paraneoplastic panel

  • Antineuronal YO.

  • Antineuronal HU.

Negative

  • ACT, adoptive cell therapy; ANCA, anti-neutrophil cytoplasmic antibodies; CMV, cytomegalovirus; CRP, C reactive protein; CSF, cerebrospinal fluid; EBV, Epstein-Barr virus; HSV, herpes simplex viru; HU, antineuronal nuclear antibody; LDH, lactate dehydrogenase; TIL, tumor-infiltrating lymphocyte; TSH, thyroid stimulating hormone; VZV, varicella zoster virus; YO, purkinje cell cytoplasmic antibody.