Variables | ∆LRχ^{2}
| P value |

PFS | ||

Proportion of CD38^{+} cells + PD-L1 + density of CD8^{+} T cells vs proportion of CD38^{+} cells | 7.86 | 0.0197* |

Density of CD38^{+}CD68^{+} macrophages + PD-L1 +density of CD8^{+} T cells vs density of CD38^{+}CD68^{+} macrophages | 8.82 | 0.0121* |

OS | ||

Proportion of CD38^{+} cells + PD-L1 + density of CD8^{+} T cells vs proportion of CD38^{+} cells | 2.24 | 0.3260 |

Density of CD38^{+}CD68^{+} macrophages + PD-L1 +density of CD8^{+} T cells vs density of CD38^{+}CD68^{+} macrophages | 1.03 | 0.5987 |

*Statistically significant, as determined with a likelihood ratio test.

LR, likelihood ratio; OS, overall survival; PD-L1, programmed death-ligand 1; PFS, progression-free survival.