Comparisons of different inflammation-related indices in predicting mortality for patients with COVID-19 with solid tumors
| Inflammation-related indices | AUC (95% CI) | P value* | Thresholds | Sensitivity (%) | Specificity (%) | OR (95% CI) † |
| WBC count, ×109/L | 0.74 (0.64 to 0.84) | – | 6.93 | 65 | 81 | 7.87 (3.64 to 17.03) |
| Lymphocyte count, ×109/L | 0.74 (0.66 to 0.82) | 0.992 | 0.70 | 73 | 70 | 6.25 (2.83 to 13.80) |
| Neutrophil count, ×109/L | 0.79 (0.69 to 0.88) | <0.001 | 5.82 | 65 | 88 | 13.17 (5.86 to 29.59) |
| NLR | 0.85 (0.78 to 0.91) | 0.015 | 7.05 | 76 | 80 | 12.35 (5.36 to 28.47) |
| dNLR | 0.85 (0.78 to 0.92) | 0.032 | 4.19 | 78 | 84 | 18.75 (7.79 to 45.11) |
*The receiver operator characteristic curves were compared by using the method developed by DeLong et al 19 and WBC count was used as the reference predictor for the comparisons.
†ORs were estimated for comparing different levels of inflammation-related indices using the optimal cutoff values as the thresholds (WBC count ≥6.93 vs <6.93 ×109/L; lymphocyte count ≤0.70 vs >0.70 ×109/L; neutrophil count ≥5.82 vs <5.82 ×109/L; NLR ≥7.05 vs <7.05; and dNLR ≥4.19 vs <4.19).
AUC, the area under the receiver operator characteristic curve; dNLR, derived NLR; NLR, neutrophil-to-lymphocyte ratio; WBC, peripheral white blood cell.