Table 1

Ligand binding affinities for TIGIT, CD226, and CD112R

Ligand/receptor affinityTIGITCD226CD96CD112R
CD1551–3 nM114–199 nM37.6 nM–
CD112Not measurable0.31–8.97 µM–88 nM

  • Ligand binding affinities for TIGIT, CD226, CD96, and CD112R have been previously reported.8 9 13 61

  • ITIM, immunoreceptor tyrosine-based inhibitory motif; TIGIT, T cell immunoreceptor with immunoglobulin and ITIM domain.