Table 1

Comparison of baseline clinicopathological characteristics based on PD-L1, B7-H3, B7-H4 and VISTA expression in CP patients

Clinical data	Total NO.	%	PD-L1expression				P value	B7-H3 expression				P value	B7-H4 expression				P value	VISTA expression				P value
			Low		High			Low		High			Negative		Positive			Low		High
			NO.	%	NO.	%		NO.	%	NO.	%		NO.	%	NO.	%		NO.	%	NO.	%
Sex
Male	86	65.2	61	46.2	25	18.9	0.4991	55	41.7	31	23.5	0.5169	52	39.1	35	26.3	0.9045	43	32.6	43	32.6	0.4747
Female	46	34.8	30	22.7	16	12.2	0.4991	32	24.2	14	10.6	0.5169	27	20.3	19	14.3	0.9045	26	19.7	20	15.1	0.4747
Age group
≤35 years	61	46.2	48	36.4	13	9.8	0.0249*	44	33.3	17	12.9	0.1622	36	22.3	25	18.9	0.8566	42	31.8	19	14.4	0.0004***
>35 years	71	52.8	43	32.6	28	21.2	0.0249*	43	32.6	28	21.2	0.1622	43	32.6	28	21.2	0.8566	27	20.5	44	33.3	0.0004***
Histopathological
ACP	89	67.4	82	62.1	7	5.3	<0.0001****	62	47	27	20.5	0.1905	49	37.1	40	30.3	0.1061	63	47.7	26	19.7	<0.0001****
PCP	43	32.6	9	6.8	34	25.8	<0.0001****	25	18.9	18	13.6	0.1905	30	22.7	13	9.9	0.1061	6	4.6	37	28	<0.0001****
Primary/recurrent
Primary	117	88.6	80	60.6	37	28	0.6961	77	58.3	40	30.3	0.9476	72	54.5	45	34.1	0.2686	60	45.5	57	43.1	0.261
Recurrent	15	11.4	11	8.3	4	3.1	0.6961	10	7.6	5	3.8	0.9476	7	5.3	8	6.1	0.2686	10	7.6	5	3.8	0.261
Tumor location
Intrasellar	28	21.2	17	12.9	11	8.3	0.4978	25	18.9	3	2.4	0.0051**	15	11.4	13	9.8	0.0048**	17	12.9	11	8.3	0.3976
Prechiasmatic	59	44.7	40	30.3	19	14.4		38	28.8	21	15.9		42	31.8	17	12.9		26	29.7	33	25
Retrochiasmatic	16	12	11	8.3	5	3.8		6	4.5	10	7.6		12	9.1	4	3		9	6.8	7	5.3
Intra-third-ventricle	29	22.1	23	17.4	6	4.5		18	13.6	11	8.3		10	7.6	19	14.4		17	12.9	12	9.1
Tumor morphology
Cystic	108	81.8	78	59.1	29	22	0.0421*	71	53.8	36	27.3	0.823	88	66.7	19	14.3	0.0013**	58	43.9	49	37.1	0.3577
Solid	25	18.2	13	9.9	12	9	0.0421*	8	8.2	9	6.8	0.823	13	9.9	12	9.1	0.0013**	11	8.4	14	10.6	0.3577
Extent of resection
GTR	104	78.8	69	52.3	35	26.5	0.2147	69	52.3	35	26.5	0.8382	62	46.9	42	31.8	0.9161	50	37.9	54	40.9	0.0629
STR	28	21.2	22	16.7	6	4.5	0.2147	18	13.6	10	7.6	0.8382	17	13	11	8.3	0.9161	19	14.4	9	6.8	0.0629
Hydrocephalus
Yes	52	39.4	44	33.3	8	6.1	0.0017**	37	28	15	11.4	0.3054	28	21.2	24	18.2	0.2567	35	26.5	17	12.9	0.0053**
No	80	60.6	47	35.6	33	25	0.0017**	50	37.9	30	22.7	0.3054	51	38.6	29	22	0.2567	34	25.8	46	34.8	0.0053**

* P<0.05; ** P<0.01; *** P<0.001; **** P<0.0001
ACP, adamantinomatous-type craniopharyngioma ; GTR, gross-total resection ; PCP, papillary-type craniopharyngioma ; STR, subtotal resection .