Cell line | Tumor type | Fn14 levels | IC50 (nmol/L) | |
GrB* | GrB(C210A)-Fc-IT4* | |||
MDA-MB-231 | Breast | ++++ | >1700 | 6 |
MDA-MB-453 | Breast | ++ | >1400 | 7 |
MDA-MB-468 | Breast | +++ | >900 | 14 |
MCF7 | Breast | ++ | >700 | 15 |
SK-BR3 | Breast | + | >700 | 65 |
HT29 | Colon | ++ | >700 | 50 |
A549 | Lung | ++ | 601 | 25 |
SKOV3 | Ovarian | ++++ | >700 | 13 |
MEF 3.5−/− | Mouse embryonic fibroblast | – | >700 | >580 |
*Mean of at least three independent experiments.
GrB, granzyme B.