Table 2

Adverse events

Adverse event	Any grade		Grade 3		Grade 4
Adverse event	No.	%	No.	%	No.	%
Total patients (n=56) with an event	52	93	37	66	7	13
Infections*	38	68	14	25	2	4
Alopecia	38	68	0		0
Nausea	37	66	1	2	0
Fatigue	36	64	2	4	0
Leukopenia	33	59	20	36	4	7
Diarrhea	28	50	2	4	0
Xerostomia	21	38	0		0
Dysphagia	19	34	6	11	0
Vomiting	16	29	1	2	0
Pain	14	25	0		0
Pruritus	13	23	0		0
Vertigo	12	21	1	2	0
Thrombopenia	12	21	0		0
Stomatitis	12	21	0		0
Exanthema	9	16	0		0
Constipation	9	16	0		0
Hypokalemia	6	11	0		0
Renal insufficiency	6	11	0		0
Tumor bleeding	5	9	1	2	0
Increased transaminases/hepatitis	4	7	3	5	1	2
Dysgeusia	3	5	1	2	0
Increased lipase/pancreatitis	1	2	1	2	0
Gout	1	2	1	2	0
Pleural effusion	1	2	1	2	0
Deep vein thrombosis	1	2	1	2	0

Adverse events of treated patients independent of relationship to treatment occurring in at least 10% of the patients and all adverse events grade 3–4.
*Reasons for infections (any grade) noticed more than once were pneumonia (n=2), wound infections (n=2) and gastric feeding tube infections (n=2).