All patients (N=249) | High-risk subgroups | |||||
Liver metastases (n=84) | Renal insufficiency (n=113) | Upper tract disease (n=58) | Elderly (n=73) | Low albumin (n=46) | ||
Renal events, n (%) | ||||||
Increased creatinine | 25 (10.0) | 7 (8.3) | 12 (10.6) | 3 (5.2) | 8 (11.0) | 5 (10.9) |
Renal/urinary disorders | 72 (28.9) | 22 (26.2) | 30 (26.5) | 16 (27.6) | 23 (31.5) | 11 (23.9) |
Pneumonitis, n (%) | 9 (3.6) | 2 (2.4)* | 2 (1.8) | 2 (3.4) | 2 (2.7) | 3 (6.5) |
Gastrointestinal events, n (%) | ||||||
Diarrhea | 55 (22.1) | 19 (22.6) | 25 (22.1) | 10 (17.2) | 16 (21.9) | 4 (8.7) |
Colitis | 1 (0.4) | 0 | 0 | 0 | 1 (0.4) | 0 |
Hepatic events, n (%) | ||||||
Increased AST level | 18 (7.2) | 11 (13.1) | 9 (8.0) | 2 (3.4) | 5 (6.8) | 3 (6.5) |
Increased ALT level | 9 (3.6) | 4 (4.8) | 6 (5.3) | 1 (1.7) | 5 (6.8) | 3 (6.5) |
Autoimmune hepatitis | 1 (0.4) | 0 | 0 | 0 | 0 | 0 |
Endocrine events, n (%) | ||||||
Hypothyroidism | 11 (4.4) | 1 (1.2) | 2 (1.8) | 3 (5.1) | 2 (2.7) | 1 (2.2) |
Adrenal insufficiency | 2 (0.8) | 1 (1.2) | 1 (0.9) | 1 (1.7) | 0 | 0 |
Infusion-related reaction, n (%) | 60 (24.1) | 23 (27.4) | 23 (20.4) | 15 (25.9) | 21 (28.8) | 13 (28.3) |
*One patient died due to pneumonitis.
ALT, alanine aminotransferase; AST, aspartate aminotransferase.