Most common treatment-related adverse events in oncolytic virus clinical trials
| Adverse event | Low grade (1–2) | High grade (3–4) | Total |
| Fever | 56 | 4 | 60 |
| Chills/rigors | 40 | 0 | 40 |
| Nausea/vomiting | 30 | 8 | 38 |
| Flu-like symptoms | 27 | 2 | 29 |
| Fatigue | 36 | 4 | 40 |
| Injection site pain | 15 | 0 | 15 |
| Other pain | 19 | 7 | 26 |
*Number of studies reporting the listed event