Table 1

Patient characteristics in oncolytic virus clinical trials

Characteristic N
Cancer type
Brain154
Breast136
Gastrointestinal577
Genitourinary207
Gynecologic185
Head and neck106
Lung197
Melanoma1000
Pediatric62
Sarcoma44
Other solid tumors*494
Hematological tumors71
Total3233
Delivery route
Intratumoral1482
Intravenous1147
Multiple†54
Other‡550
Total3233
Study phase
I1008
I/II92
II714
III477
Not specified942
Total3233
  • *Includes studies enrolling solid tumors without defining the histology and unspecified patients.

  • †In some studies, patients received virus by both intravenous and intratumoral or were given different routes based on tumor location.

  • ‡Includes intravesical, intraperitoneal, intradermal, hepatic artery infusion, convection-enhanced delivery, direct injection of resected tumor bed.