Table 3

Treatment-related adverse events

Adverse event, n(%)Grade 1–2 (%)Grade 3 (%)Grade 4 (%)
Dysphonia36 (67)0 (0)0 (0)
Lymphopenia25 (46)2 (4)0 (0)
Diarrhea24 (44)2 (4)0 (0)
Hypertension22 (41)4 (7)0 (0)
Fatigue21 (39)4 (7)0 (0)
Thrombocytopenia24 (44)1 (2)0 (0)
Erythrocytosis18 (33)0 (0)0 (0)
Thyroid-stimulating hormone increase15 (28)1 (2)0 (0)
Alanine aminotransferase increase13 (24)1 (2)0 (0)
Mucositis/aphtosis13 (24)0 (0)0 (0)
Neutrophilia9 (17)0 (0)0 (0)
Aspartate aminotransferase increase8 (15)1 (2)0 (0)
Gamma-glutamyltransferase increase4 (7)5 (9)0 (0)
Anorexia7 (13)1 (2)0 (0)
Alkaline phosphatase increase6 (11)0 (0)0 (0)
Headache6 (11)0 (0)0 (0)
Chills-acute infusion reaction6 (11)0 (0)0 (0)
Oral dysesthesia5 (9)0 (0)0 (0)
Pruritus5 (9)0 (0)0 (0)
Fever-acute infusion reaction5 (9)0 (0)0 (0)
Dry mouth4 (7)0 (0)0 (0)
Arthralgia4 (7)0 (0)0 (0)
Abdominal pain4 (7)0 (0)0 (0)
Rash papulopustular4 (7)0 (0)0 (0)
Eosinophilia4 (7)0 (0)0 (0)
Pulmonary embolism0 (0)0 (0)3 (6)
Rash3 (6)0 (0)0 (0)
Nausea3 (6)0 (0)0 (0)
Confusion2 (4)1 (2)0 (0)
Constipation3 (6)0 (0)0 (0)
Thyroid-stimulating hormone decrease3 (6)0 (0)0 (0)
Dyspnea1 (2)1 (2)0 (0)
Hepatitis1 (2)1 (2)0 (0)
Myalgia2 (4)0 (0)0 (0)
Periodontal disease2 (4)0 (0)0 (0)
Rash seborrheic2 (4)0 (0)0 (0)
Rhinitis2 (4)0 (0)0 (0)
Urinary frequency2 (4)0 (0)0 (0)
Neutropenia2 (4)0 (0)0 (0)
Creatine kinase increase1 (2)1 (2)0 (0)
Acute kidney injury0 (0)1 (2)0 (0)
Hypothyroidism1 (2)0 (0)0 (0)
Dysphagia1 (2)0 (0)0 (0)
Erythema1 (2)0 (0)0 (0)
Impaired consciousness0 (0)1 (2)0 (0)
Intracranial hemorrhage0 (0)1 (2)0 (0)
Petechiae1 (2)0 (0)0 (0)
Pneumonitis0 (0)1 (2)0 (0)
Rash maculopapular1 (2)0 (0)0 (0)
Rash psoriasiform1 (2)0 (0)0 (0)
Subcutaneous swelling1 (2)0 (0)0 (0)
Microscopic colitis1 (2)0 (0)0 (0)
Vomiting1 (2)0 (0)0 (0)
Lymphocytosis1 (2)0 (0)0 (0)
Xerophtalmia1 (2)0 (0)0 (0)
Xerosis1 (2)0 (0)0 (0)