Table 1

Baseline characteristics of the study population

Overall population
(n=54)
Cohort-1
(n=27)
Cohort-2
(n=27)
Sex, n(%)
Male34 (63)14 (52)20 (74)
Female20 (37)13 (48)7 (26)
Median age at treatment initiation, years55 (range 19–75)57 (range 20–70)47 (range 19–75)
ECOG performance status, n(%)
027 (50)20 (74)7 (26)
122 (41)6 (22)16 (59)
25 (9)1 (4)4 (15)
Diagnosis, n(%)
Primary diagnosis of grade IV glioma37 (69)18 (67)19 (70)
Primary diagnosis of lower-grade glioma with evolution to high-grade glioma17 (31)9 (33)8 (30)
Molecular profile, n(%)
IDH1/2 mutation
  Mutant10 (19)5 (19)5 (19)
  Wild-type34 (63)20 (74)14 (52)
  Unknown10 (19)2 (7)8 (30)
MGMT promotor
  Methylated6 (11)3 (11)3 (11)
  Unmethylated14 (26)8 (30)6 (22)
  Unknown34 (63)16 (59)18 (67)
1 p/19q codeletion
  Yes4 (7)1 (4)3 (11)
  No19 (35)11 (41)8 (30)
  Unknown31 (57)15 (56)16 (59)
Use of oral corticosteroid therapy at treatment initiation, n(%)31 (57)4 (15)27 (100)
Median daily dose of methylprednisolone at baseline8 mg32 mg
Prior therapy for primary diagnosis of glioma, n(%)
Primary surgery for diagnosis
  Resection47 (87)24 (89)23 (85)
  Biopsy7 (13)3 (11)4 (15)
Primary therapeutic strategy
  Resection/biopsy only7 (13)3 (11)4 (15)
  Radiation therapy only1 (2)0 (0)1 (4)
  Chemotherapy only1 (2)0 (0)1 (4)
  Surgery+chemotherapy only1 (2)1 (4)0 (0)
  Surgery+radiation therapy only3 (6)2 (7)1 (4)
  Surgery+radiation therapy +chemotherapy (sequential)1 (2)0 (0)1 (4)
  Surgery+concomitant radiation therapy/TMZ+adjuvant TMZ40 (74)21 (78)19 (70)
Prior therapy for recurrent GB, n(%)39 (72)20 (74)19 (70)
Surgery33 (61)18 (33)15 (56)
  Median no of surgeries1 (range 1–4)1 (range 1–2)1 (range 1–4)
Radiation therapy11 (20)6 (22)5 (19)
Systemic therapy33 (61)16 (59)17 (63)
  Median no of lines of systemic therapy1 (range 1–4)1 (range 1–4)1 (range 1–3)
  • 1 p/19q codeletion: deletion of short arm of chromosome one and long arm of chromosome 19.

  • ECOG, Eastern Cooperative Oncology Group; GB, glioblastoma; IDH, isocitrate dehydrogenase; MGMT, O-6-methylguanine-DNA methyltransferase; TMZ, temozolomide.