Table 1

The concordance between next generation sequencing (NGS) blood microsatelliteinstability (bMSI) with PCR tissue MSI (tMSI)

PCR tMSI Total
+
NGS bMSI+33841
7201208
Total40209249
Sensitivity=82.5% (33/40, 95% CI 70.2% to 94.8%)
Specificity=96.2% (201/209, 95% CI 93.5% to 98.8%)
PPV=80.5% (33/41, 95% CI 67.8% to 93.2%)
NPV=96.6% (201/208, 95% CI 94.2% to 99.1%)
Concordance=94.0% (234/249, 95% CI 91.0% to 97.0%)
  • NPV, negative predictive value; PPV, positive predictive value.