Table 3

Cox proportional-hazards regression: multivariable analyses

VariablePFSOS
HR (95% CI)P valueHR (95% CI)P value
A
 Pretreatment BMI trend1.27 (1.05 to 1.54)0.021.61 (1.27 to 2.05)<0.001
 Low PNI1.34 (1.06 to 1.69)0.011.65 (1.27 to 2.13)<0.001
B
 Pretreatment BMI trend1.27 (1.01 to 1.59)0.041.56 (1.21 to 2.00)0.001
 Low PNI1.34 (1.06 to 1.70)0.011.66 (1.28 to 2.15)<0.001
C
 Pretreatment BMI trend1.10 (1.00 to 1.22)0.051.19 (1.08 to 1.32)0.001
 Low PNI1.72 (1.36 to 2.17)<0.0011.62 (1.25 to 2.10)<0.001
D
 Pretreatment BMI trend1.29 (1.06 to 1.58)0.011.62 (1.26 to 2.08)<0.001
 Low PNI1.32 (1.02 to 1.70)0.031.53 (1.15 to 2.03)0.003
  • (A) All patients; any decrease in pretreatment BMI (reference: no decrease). (B) All patients; BMI decrease ≥2% (reference: all other patients). (C) All patients; pretreatment BMI change as a continuous variable. (D) Non-cachectic patients; any decrease in pretreatment BMI (reference: no decrease).

  • OS, overall survival; PFS, progression-free survival; PNI, prognostic nutritional index.