Table 1

Features of colitis

Overall (n=115)*PD1 (n=35)IPI+ PD1 (n=80)P value
Time to colitis (weeks)<0.001
 Median (range)6.2 (0.5, 201.5)25.7 (1.5, 201.5)6.3 (0.5, 57.6)
Cycles of immunotherapy to colitis, n (%)<0.0001
 Median (range)2 (1,46)8 (1,46)1 (1,6)
Colitis grade, n (%)<0.001
 G1 and G251 (44.3)24 (68.6)27 (33.8)
 G3 and G464 (55.7)11 (31.4)53 (66.3)
Endoscopic and histopathological features, n (%)†64 (56%)20 (57%)44 (55%)
Type of endoscopy, n (%)0.97
 Colonoscopy29 (45.3)9 (45.0)20 (45.0)
 Sigmoidoscopy35 (54.7)11 (55.0)24 (54.5)
Time to endoscopy (days)0.11
 Median(range)10 (0–91)10 (0–37)13.5 (1–91)
Treatment before endoscopy0.04
 Oral steroid only38 (59.4)17 (85.0)21 (47.7)
 Oral + intravenous steroid20 (31.3)2 (10.0)18 (40.9)
 Steroid + infliximab2 (3.1)0 (0.0)2 (4.5)
 None4 (6.3)1 (5.0)3 (6.8)
Area of colon affected, n (%)0.42
 Rectum only4 (6.3)1 (5.3%)3 (6.8)
 Sigmoid colon only14 (22.2)7 (36.8)7 (15.9)
 Left colon (sigmoid + rectum)15 (23.4)4 (20.0)11 (25.0)
 Right colon (includes ileum)3 (4.8)2 (10.5)1 (2.3)
 Pancolon15 (23.8)2 (10.5)13 (29.5)
 None13 (20.6)4 (21.1)9 (20.5)
Intraepithelial neutrophilic infiltrate, n (%)0.03
 Absent19 (29.7)10 (50.0)9 (20.5)
 <5% crypts involved22 (34.4)7 (35.0)15 (34.1)
 <50% crypts involved13 (20.3)3 (15.0)10 (22.7)
 >50% crypts involved10 (15.6)0 (0.0)10 (22.7)
Intraepithelial lymphocytosis, grade0.01
 Absent43 (67.2)9 (45.0)34 (77.3)
 Borderline (1–20/100 HPF)13 (20.3)5 (25.0)8 (18.2)
 Severe (>20/100 HPF)8 (12.5)6 (30.0)2 (4.5)
Location of intraepithelial lymphocytosis, n (%)<0.01
 Absent43 (67.2)9 (45.0)34 (77.3)
 Crypt predominant12 (18.8)4 (20.0)8 (18.2)
 Crypt and superficial9 (14.1)7 (35.0)2 (4.50)
Erosion, n (%)0.04
 Absent51 (79.7)19 (95.0)32 (72.7)
 Present13 (20.3)1 (5.0)12 (27.3)
  • *Excluding three patients with ipilimumab only.

  • †Endoscopic and histolopathological data available on 64/115 patients (56%); 20 (20/35 57%) in PD1 and 44 (44/80, 55%) in IPI+PD1 cohort.

  • HPF, High power field; IPI, ipilimumab; PD1, programmed cell death protein 1.