Table 1

Clinical vaccination studies in Ewing sarcoma

StatusPhaseType of vaccineAntigenTrial number
RIIITC transfected with rhGM-CSF/RNAi bi-shRNAfurin+temozolimideAutologous tumor cellsNCT03495921
CIDC+adjuvantNY-ESO-1, MAGEA1, MAGEA3NCT01241162
CIIIDC+autologous T cellsEWS/FLI-1NCT00001566
CITC transfected with rhGM-CSF/RNAi bi-shRNAfurinAutologous tumor cellsNCT01061840
CIAntigen presenting cells (APC)+IL-2±autologous T cellsEWS/FLI-1NCT00001564
CI/IIDC+IL-7+autologous T cellsTumor cell lysateNCT00923351
CIDC+decitabineNY-ESO-1, MAGEA1 and MAGEA3NCT01241162
CIITC transfected with rhGM-CSF/RNAi bi-shRNAfurin+temozolimideAutologous tumor cellsNCT01241162
CIRacotumomab anti-idiotype antibodyNCT01598454
CIPeptide+adjuvantMAGEA12NCT00020267
  • C, completed; DC, dendritic cells; IL, interleukin; R, recruiting; rhGM-CSF, recombinant human granulocyte macrophage-colony stimulating factor; TC, tumor cells.