Table 1

Summary of The Oxford Levels of Evidence 2

Level 1Level 2Level 3Level 4Level 5
Systematic review or meta-analysisRandomized trial or observational study with dramatic effectNon-randomized controlled cohort or follow-up studyCase series, case–control or historically controlled studyMechanism-based reasoning
  • Adapted from OCEBM (Oxford Center for Evidence-Based Medicine) Levels of Evidence Working Group, “The Oxford Levels of Evidence 2.”26