Multivariate analysis for associations between clinical factors and OS in patients without brain metastases
| Variable | Factor | N=185 | VTE no. (%) | 2-year OS (95% CI) | HR | 95% CI | P value |
| TE after ICI | No | 154 | 53 (34) | 71.3 (64.0 to 78.5) | |||
| Yes | 31 | 21 (68) | 50.8 (33.0 to 68.6) | 2.27 | 1.36 to 3.79 | 0.002 | |
| Age at treatment start, years | ≤65 | 88 | 25 (28) | 75.8 (66.8 to 84.9) | |||
| >65 | 97 | 49 (51) | 60.2 (50.2 to 70.2) | 2.22 | 1.36 to 3.60 | <0.001 | |
| Stage at treatment start | III | 43 | 2 (5) | 100.0 (100.0 to 100.0) | |||
| IV | 142 | 72 (51) | 58.3 (50.1 to 66.5) | 12.16 | 2.98 to 49.64 | <0.001 |
ICI, immune checkpoint inhibitor; OS, overall survival; TE, thromboembolism; VTE, venous thromboembolism.